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Apply These Secret WAYS TO Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unaware of the statistics surrounding miscarriage, pregnancy loss is in fact quite common, with 10-25% of recognized pregnancies ending in miscarriage. When you have suffered a pregnancy loss or are currently in the process of experiencing a miscarriage, you may well be wondering what caused the loss and worry about whether it’ll happen again. This article aims to answer the following questions:

What causes miscarriage?
How common is pregnancy loss?
Which kind of genetic testing is available for miscarriage tissue?
pregnancy loss How can chromosome testing help?
Causes of Miscarriage

There are many different reasons why miscarriage occurs, but the most typical cause for first trimester miscarriage is a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also called “aneuploidy” – occur due to a mis-division of the chromosomes in the egg or sperm involved with a conception. Typically, humans have 46 chromosomes that come in 23 pairs (22 pairs numbered from 1 to 22 and then the sex chromosomes, X and Y). For a baby to develop normally it is necessary that it have the right level of chromosome material; missing or extra material at the time of conception or within an embryo or fetus could cause a female to either not get pregnant, miscarry, or have a child with a chromosome syndrome such as Down syndrome.

Over 50% of most first trimester miscarriages are caused by chromosome abnormalities. This number could be closer to 75% or more for women aged 35 years and over who’ve experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep upsurge in women older than 35.

Pregnancy Loss – How Common could it be?

Miscarriage is far more common than a lot of people think. Up to one atlanta divorce attorneys four recognized pregnancies is lost in first trimester miscarriage. The chance of experiencing a miscarriage also increases as a mother gets older.

Nearly all women who experience a miscarriage go on to possess a healthy pregnancy and never miscarry again. However, some women appear to be more prone to miscarriage than others. About five percent of fertile couples will experience two or more miscarriages.

Of note, the rate of miscarriage appears to be increasing. One reason for this can be awareness – more women know they’re having a miscarriage because home pregnancy tests have improved early pregnancy detection rates in the last decade, whereas in the past the miscarriage would have appeared to be just a unique period. Another reason may be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually refers to many types of testing that can be done on the DNA in a cell. For miscarriage tissue, also known as products of conception (POC), probably the most useful type of test to perform is a chromosome analysis. A chromosome analysis (also known as chromosome testing) can examine all 23 pairs of chromosomes for the current presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are caused by aneuploidy, chromosome analysis on the miscarriage tissue could identify the reason behind the pregnancy loss.

The most common approach to chromosome analysis is named karyotyping. Newer methods include advanced technologies such as microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. Because of this requirement, tissue that is passed at home is often unable to be tested with this method. About 20% or even more of miscarriage samples fail to grow and thus no email address details are available. Additionally, karyotyping is unable to tell the difference between cells from the mother (maternal cells) and cells from the fetus. If a normal female result is found, it may be the right result for the fetus or it might be maternal cell contamination (MCC) where the result actually originates from testing the mother’s cells present in the pregnancy tissue rather than the fetal cells. MCC seems to occur in about 30% or more of the samples tested by traditional karyotype. Results from karyotyping usually have a few weeks to months another from the laboratory.

Microarray testing is really a new kind of genetic testing done on miscarriage samples; the two most common types of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing is also able to test all 23 pairs of chromosomes for aneuploidy, but will not require cell culture. Therefore, you’re more prone to receive results and the results are typically returned faster when microarray testing can be used. Additionally, some laboratories are collecting a sample of the mother’s blood as well the miscarriage tissue is sent to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How can it help?

In case a chromosome abnormality is identified, the kind of abnormality found can be assessed to help answer fully the question: “Will this happen to me again?”. More often than not, chromosome abnormalities within an embryo or fetus aren’t inherited and have a low possiblity to occur in future pregnancies. Sometimes, a specific chromosome finding in a miscarriage alerts your physician to do further studies to research the possibility of an underlying genetic or chromosome problem in your family that predisposes one to have miscarriages.

Furthermore, in case a chromosome abnormality is identified it could prevent the dependence on other, sometimes quite costly, studies your physician might consider to investigate the reason for the miscarriage.

Lastly, knowing the reason for a pregnancy loss can help a couple start the emotional healing up process, moving at night question of “Why did this happen to me?”.

Chromosome testing could be especially important for patients with repeated miscarriages, as it could either give clues to an underlying chromosomal cause for the miscarriages or rule out chromosome errors as the reason for the miscarriages and invite their doctor to pursue other styles of testing. For couples with multiple miscarriages determined to have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing might be able to help increase their likelihood of having a successful healthy pregnancy.